Engineering Immune Organoids : An Interview with Prof. Ankur Singh from Cornell University / Ingegneria degli Organoidi Immuni: Intervista con Prof. Ankur Singh dell'Università di Cornell
Segnalato dal Dott. Giuseppe Cotellessa / Reported by Dr. Giuseppe Cotellessa
B cell lymphomas grow in organoids as clusters, similar to those in patients. The green fluorescent areas represent lymphoma cells, while the red represents support stromal cells.
I linfomi di cellule B crescono in organoidi come cluster, simili a quelli dei pazienti. Le aree fluorescenti verdi rappresentano le cellule del linfoma, mentre il rosso rappresenta le cellule stromali di supporto.
Organ-on-a-chip technologies are redefining the way in which in vitro models help understand and recapitulate the in vivo environment. The immune system is particularly difficult to model in an in vitro environment because of the complexity of biological, mechanical, and chemical cues that modulate the immune cells. Prof. Ankur Singh, an assistant professor in the Sibley School of Mechanical and Aerospace Engineering at Cornell University, has led the development of organ-on-a-chip models to mimic the complex immune environment.